Chlorhexidine anaphylaxis in Auckland.
نویسنده
چکیده
infusion as demonstrated in Figure 3 in our article. Opioid consumption on the other hand is an indirect measure of pain intensity. We agree that PCB is associated with an opioid-sparing effect, and therefore a lower cumulative opioid intake after surgery. Our review shows significantly lower opioid consumption up to 24 h after surgery. Cumulative opioid consumption, however, provides no information on the duration of block with PCB. In fact, as a result of opioid sparing in the early postoperative period, cumulative opioid consumption would be expected to be lower in patients who have received a PCB at all time periods after surgery. To estimate the duration of block with PCB using opioid consumption, it makes more sense to analyse hourly opioid consumption or opioid consumption over short time intervals within a 48 h period. Unfortunately, these data are not available in the literature we identified for review. We therefore reiterate our finding that compared with the gold standard (postoperative opioid titration), PCB is only effective for analgesia during the first 4–8 h after surgery. This analgesic effect results in reduced opioid titration in the early postoperative period which in turn results in a lower cumulative opioid intake after surgery. This conclusion is consistent with Dr Byreddy’s findings, although we cannot confirm his observation of reduced cumulative opioid consumption beyond 24 h as a result of lack of data in the studies we analysed. Our conclusion also supports the PROSPECT guidelines on single-injection PCB for hip surgery which recommends a cautious appraisal of the risk/ benefit ratio of single-injection PCB on a case-by-case basis.
منابع مشابه
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1990s [7–9] . We and other study groups have shown that a significant proportion (5–10%) of IgE-mediated anaphylaxis occurring during general anaesthesia is triggered by chlorhexidine [8, 10, 11] . To put this into perspective, the incidence rate of peri-operative (all causes) anaphylaxis during anaesthesia has been estimated to be 1 in 10,000–20,000 in France and Australia [12, 13] . Hong et a...
متن کاملPeri-operative anaphylaxis: beyond drugs and latex.
1990s [7–9] . We and other study groups have shown that a significant proportion (5–10%) of IgE-mediated anaphylaxis occurring during general anaesthesia is triggered by chlorhexidine [8, 10, 11] . To put this into perspective, the incidence rate of peri-operative (all causes) anaphylaxis during anaesthesia has been estimated to be 1 in 10,000–20,000 in France and Australia [12, 13] . Hong et a...
متن کاملPeri-Operative Anaphylaxis: Beyond Drugs and Latex
1990s [7–9] . We and other study groups have shown that a significant proportion (5–10%) of IgE-mediated anaphylaxis occurring during general anaesthesia is triggered by chlorhexidine [8, 10, 11] . To put this into perspective, the incidence rate of peri-operative (all causes) anaphylaxis during anaesthesia has been estimated to be 1 in 10,000–20,000 in France and Australia [12, 13] . Hong et a...
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Chlorhexidine is an antiseptic and disinfectant used in surgical and clinical practice since 1954 and is available in aqueous or alcoholic solutions 0.5%-4.0% and has a broad-spectrum activity. Despite their widespread use, allergic reactions with chlorhexidine are rarely reported. We describe a case of anaphylaxis with chlorhexidine during a septoplasty, turbinectomy, and maxillary sinusectomy...
متن کاملLife-threatening Chlorhexidine Anaphylaxis: A Case Report
Chlorhexidine is a common antiseptic and disinfectant used in the medical field. Allergy to chlorhexidine has been reported in the literature but life-threatening anaphylactic shock is rare. We present a case of severe anaphylactic shock due to chlorhexidine occurring during surgery. Literatures suggest that profound anaphylactic shock to chlorhexidine is commonly preceded by milder, non-specif...
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عنوان ژورنال:
- British journal of anaesthesia
دوره 102 5 شماره
صفحات -
تاریخ انتشار 2009